{"id":2062,"date":"2016-10-16T00:41:45","date_gmt":"2016-10-15T22:41:45","guid":{"rendered":"http:\/\/rand-biotech.com\/es\/home-sp\/isolated-organ-perfusion\/"},"modified":"2017-12-05T18:22:38","modified_gmt":"2017-12-05T17:22:38","slug":"ilp-perfusion-de-organo-aislado","status":"publish","type":"page","link":"https:\/\/rand-biotech.com\/es\/rand-biotech-innovacion-en-tecnologia-medica\/ilp-perfusion-de-organo-aislado\/","title":{"rendered":"ILP &#8211; ESP"},"content":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;h1&#8243; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243;]PERFUSI\u00d3N DE \u00d3RGANO AISLADO[\/vc_custom_heading][vc_separator sep_color=&#8221;color-wvjs&#8221; el_width=&#8221;200px&#8221; el_height=&#8221;2&#8243;][vc_column_text]La perfusi\u00f3n de una extremidad aislada se logra mediante canulaci\u00f3n de los dos vasos sangu\u00edneos principales, una arteria y una vena, tras la exclusi\u00f3n vascular completa de todos los vasos colaterales y el posicionamiento de un torniquete hemost\u00e1tico en la base de la extremidad. Tras haber alcanzado un aislamiento vascular completo, la perfusi\u00f3n de la extremidad se logra de una manera selectiva con solo una m\u00ednima p\u00e9rdida de sangre hacia la circulaci\u00f3n sist\u00e9mica. El aislamiento vascular de la extremidad se podr\u00eda obtener mediante radiolog\u00eda intervencionista, con el uso de unos cat\u00e9teres especiales a forma de bal\u00f3n. Tras el aislamiento quir\u00fargico o radiol\u00f3gico, la perfusi\u00f3n de la extremidad se realiza mediante la recirculaci\u00f3n de la sangre, previamente oxigenada y calentada a 39-42 \u00b0C. Los f\u00e1rmacos quimioter\u00e1picos y\/o citoquinas se a\u00f1aden eventualmente a la sangre durante la fase de recirculaci\u00f3n hipert\u00e9rmica, que normalmente dura 60 minutos.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243; text_color=&#8221;color-163594&#8243;]Melanoma y sarcomas del tejido blando de la extremidad[\/vc_custom_heading][vc_column_text]El melanoma y los sarcomas del tejido blando son tumores malignos que se originan de la piel y de los tejidos blandos conectivos. La perfusi\u00f3n hipert\u00e9rmica aislada de la extremidad (ILP) con f\u00e1rmacos quimioter\u00e1picos es una modalidad de tratamiento aceptada que consigue el control local en estadios avanzados de melanoma de las extremidades o recurrencia del tumor tras la extirpaci\u00f3n mediante cirug\u00eda. En estadios avanzados, los melanomas de la extremidad en los que las c\u00e9lulas malignas emigran a los tejidos cercanos y\/o a ganglios linf\u00e1ticos locales, por ejemplo la met\u00e1stasis en tr\u00e1nsito,<strong>\u00a0la perfusi\u00f3n de una extremidad aislada es el procedimiento m\u00e1s eficaz para obtener un control local y para lograr salvar la extremidad.<\/strong>\u00a0Se obtienen resultados parecidos en los sarcomas de tejidos blancos no resecables.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243; text_color=&#8221;color-163594&#8243;]Indicaciones cl\u00ednicas[\/vc_custom_heading][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; equal_height=&#8221;yes&#8221; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; style=&#8221;dark&#8221; gutter_size=&#8221;3&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]1.[\/vc_custom_heading][vc_column_text]El melanoma de la extremidad con met\u00e1stasis en tr\u00e1nsito (Estadio IIIA, seg\u00fan el sistema de calificaci\u00f3n del MD Anderson Cancer Center).[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; back_color=&#8221;color-gyho&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]2.[\/vc_custom_heading][vc_column_text]El melanoma de la extremidad con met\u00e1stasis en tr\u00e1nsito a los ganglios linf\u00e1ticos locales (Estadio IIIB, seg\u00fan el sistema de calificaci\u00f3n del MD Anderson Cancer Center).[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; style=&#8221;dark&#8221; gutter_size=&#8221;3&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]3.[\/vc_custom_heading][vc_column_text]Asociaci\u00f3n de los dos estadios anteriormente indicados (Estadio IIIAB, seg\u00fan el sistema de calificaci\u00f3n del MD Anderson Cancer Center).[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; back_color=&#8221;color-gyho&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]4.[\/vc_custom_heading][vc_column_text]Sarcomas de tejidos blandos no resecables en la extremidad y en un estadio inicial o localmente avanzado.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243; text_color=&#8221;color-163594&#8243;]Ventajas del ILP[\/vc_custom_heading][vc_column_text]Las ventajas del ILP, en comparaci\u00f3n con la quimioterapia sist\u00e9mica (ya sea neoadyuvante o adyuvante):[\/vc_column_text][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; equal_height=&#8221;yes&#8221; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; style=&#8221;dark&#8221; gutter_size=&#8221;3&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]1.[\/vc_custom_heading][vc_column_text]La posibilidad de utilizar concentraciones mucho mayores y, consecuentemente, mucho m\u00e1s eficaces, de f\u00e1rmacos quimioter\u00e1picos citot\u00f3xicos.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; back_color=&#8221;color-gyho&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]2.[\/vc_custom_heading][vc_column_text]La reducida absorci\u00f3n sist\u00e9mica del f\u00e1rmaco citot\u00f3xico (a trav\u00e9s del aislamiento vascular y la perfusi\u00f3n selectiva de la extremidad), dando como resultado una toxicidad sist\u00e9mica reducida.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; style=&#8221;dark&#8221; gutter_size=&#8221;3&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]3.[\/vc_custom_heading][vc_column_text]La posibilidad de eliminar, al finalizar el proceso, el f\u00e1rmaco no absorbido por la extremidad.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; back_color=&#8221;color-gyho&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]4.[\/vc_custom_heading][vc_column_text]La posibilidad de administrar el f\u00e1rmaco de manera localizada a una elevada temperatura, aumentando la actividad citot\u00f3xica y la penetraci\u00f3n en la masa tumoral.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243; text_color=&#8221;color-163594&#8243;]F\u00e1rmacos citot\u00f3xicos usados en la ILP[\/vc_custom_heading][vc_column_text]Los f\u00e1rmacos com\u00fanmente usados en la IP son <strong>Melfal\u00e1n y\/o Doxorrubicina<\/strong>. Debido a la toxicidad sist\u00e9mica, la inyecci\u00f3n adicional del Tumor Necrosis Factor-\u03b1 (TNF- \u03b1) en la ILP se debe realizar solo tras haber completado el aislamiento vascular completo de la extremidad y la monitorizaci\u00f3n de la p\u00e9rdida de sangre. La p\u00e9rdida de sangre de la extremidad aislada se monitoriza tras la inyecci\u00f3n de alb\u00famina marcada isot\u00f3picamente y solo una detecci\u00f3n inferior al 10% de radioactividad en la circulaci\u00f3n sist\u00e9mica se considera como segura para el paciente.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_separator][\/vc_column][\/vc_row][vc_row unlock_row_content=&#8221;yes&#8221; row_height_percent=&#8221;40&#8243; parallax=&#8221;yes&#8221; overlay_alpha=&#8221;45&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243;][vc_column column_width_percent=&#8221;100&#8243; position_vertical=&#8221;middle&#8221; align_horizontal=&#8221;align_center&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;300&#8243; text_transform=&#8221;uppercase&#8221;]\u00bfQUIERE RECIBIR MAYOR INFORMACI\u00d3N?[\/vc_custom_heading][vc_button button_color=&#8221;color-692600&#8243; size=&#8221;btn-lg&#8221; border_animation=&#8221;btn-ripple-out&#8221; link=&#8221;url:mailto%3Ainfo%40rand-biotech.com|||&#8221;]ENV\u00cdENOS UN CORREO ELECTR\u00d3NICO[\/vc_button][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;h1&#8243; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243;]PERFUSI\u00d3N DE \u00d3RGANO AISLADO[\/vc_custom_heading][vc_separator sep_color=&#8221;color-wvjs&#8221; el_width=&#8221;200px&#8221; el_height=&#8221;2&#8243;][vc_column_text]La perfusi\u00f3n de una extremidad aislada se logra mediante canulaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":2047,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2062","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ILP - perfusi\u00f3n de \u00f3rgano aislado<\/title>\n<meta name=\"description\" content=\"La perfusi\u00f3n de una extremidad aislada es el procedimiento m\u00e1s eficaz para obtener un control local y para lograr salvar la extremidad.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rand-biotech.com\/es\/rand-biotech-innovacion-en-tecnologia-medica\/ilp-perfusion-de-organo-aislado\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ILP - perfusi\u00f3n de \u00f3rgano aislado\" \/>\n<meta property=\"og:description\" content=\"La perfusi\u00f3n de una extremidad aislada es el procedimiento m\u00e1s eficaz para obtener un control local y para lograr salvar la extremidad.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rand-biotech.com\/es\/rand-biotech-innovacion-en-tecnologia-medica\/ilp-perfusion-de-organo-aislado\/\" \/>\n<meta property=\"og:site_name\" content=\"RAND\" \/>\n<meta property=\"article:modified_time\" content=\"2017-12-05T17:22:38+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/rand-biotech.com\\\/es\\\/rand-biotech-innovacion-en-tecnologia-medica\\\/ilp-perfusion-de-organo-aislado\\\/\",\"url\":\"https:\\\/\\\/rand-biotech.com\\\/es\\\/rand-biotech-innovacion-en-tecnologia-medica\\\/ilp-perfusion-de-organo-aislado\\\/\",\"name\":\"ILP - perfusi\u00f3n de \u00f3rgano aislado\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/rand-biotech.com\\\/#website\"},\"datePublished\":\"2016-10-15T22:41:45+00:00\",\"dateModified\":\"2017-12-05T17:22:38+00:00\",\"description\":\"La perfusi\u00f3n de una extremidad aislada es el procedimiento m\u00e1s eficaz para obtener un control local y para lograr salvar la extremidad.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/rand-biotech.com\\\/es\\\/rand-biotech-innovacion-en-tecnologia-medica\\\/ilp-perfusion-de-organo-aislado\\\/#breadcrumb\"},\"inLanguage\":\"es-ES\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/rand-biotech.com\\\/es\\\/rand-biotech-innovacion-en-tecnologia-medica\\\/ilp-perfusion-de-organo-aislado\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/rand-biotech.com\\\/es\\\/rand-biotech-innovacion-en-tecnologia-medica\\\/ilp-perfusion-de-organo-aislado\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/rand-biotech.com\\\/es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"HOME &#8211; 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