{"id":1986,"date":"2016-10-16T00:41:45","date_gmt":"2016-10-15T22:41:45","guid":{"rendered":"http:\/\/rand-biotech.com\/fr\/extra-us\/isolated-organ-perfusion\/"},"modified":"2017-09-28T12:17:54","modified_gmt":"2017-09-28T10:17:54","slug":"ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb","status":"publish","type":"page","link":"https:\/\/rand-biotech.com\/fr\/rand-biotech-innovation-dans-la-technologie-medicale\/ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb\/","title":{"rendered":"ILP &#8211; FR"},"content":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;h1&#8243; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243;]PERFUSION DE MEMBRE ISOLE[\/vc_custom_heading][vc_separator sep_color=&#8221;color-wvjs&#8221; el_width=&#8221;200px&#8221; el_height=&#8221;2&#8243;][vc_column_text]La perfusion d\u2019un membre isol\u00e9 est obtenue gr\u00e2ce \u00e0 la canulation chirurgicale des deux principaux vaisseaux sanguins, une art\u00e8re et une veine, apr\u00e8s l\u2019exclusion vasculaire compl\u00e8te de tous les vaisseaux collat\u00e9raux et le positionnement d\u2019un garrot \u00e0 la base du membre. Apr\u00e8s avoir obtenu l\u2019isolation vasculaire compl\u00e8te, la perfusion des membres est effectu\u00e9e d\u2019une mani\u00e8re s\u00e9lective avec seulement une perte minime de sang dans la circulation syst\u00e9mique. L&#8217;isolement vasculaire du membre pourrait \u00eatre obtenu par une intervention radiologique, avec l\u2019utilisation de cath\u00e9ters sp\u00e9ciaux \u00e0 ballonnet. Apr\u00e8s l\u2019isolement vasculaire chirurgical ou radiologique, la perfusion du membre est effectu\u00e9e en faisant circuler de nouveau le sang pr\u00e9c\u00e9demment oxyg\u00e9n\u00e9 et r\u00e9chauff\u00e9 entre 39\u00b0 et 42\u00b0 C. Les m\u00e9dicaments de la chimioth\u00e9rapie et\/ou cytokines sont ensuite ajout\u00e9s dans le sang durant la phase de recirculation hyperthermique qui dure normalement 60 minutes.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243; text_color=&#8221;color-163594&#8243;]Sarcomes du m\u00e9lanome et des tissus mous du membre[\/vc_custom_heading][vc_column_text]Les sarcomes du m\u00e9lanome et des tissus mous sont des tumeurs malignes provenant de la peau et des tissus conjonctifs souples. La perfusion hyperthermique des membres isol\u00e9s (ILP) avec des m\u00e9dicaments de chimioth\u00e9rapie est une modalit\u00e9 de traitement accept\u00e9e qui atteint le contr\u00f4le locor\u00e9gionale dans le m\u00e9lanome \u00e0 un stade avanc\u00e9 des extr\u00e9mit\u00e9s ou de la rechute tumorale apr\u00e8s l\u2019excision chirurgicale. A un stade avanc\u00e9, les m\u00e9lanomes du membre o\u00f9 les cellules malignes se sont d\u00e9plac\u00e9es dans les tissus environnants et\/ou dans les ganglions lymphatiques r\u00e9gionaux, c\u2019est-\u00e0-dire dans les m\u00e9tastases en transit. <strong>L&#8217;ILP est la proc\u00e9dure la plus efficace pour obtenir un contr\u00f4le local et afin de pouvoir sauver les membres. <\/strong>Des r\u00e9sultats similaires sont obtenus pour le sarcome du tissu mou non r\u00e9s\u00e9cable du membre.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243; text_color=&#8221;color-163594&#8243;]Indications cliniques[\/vc_custom_heading][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; equal_height=&#8221;yes&#8221; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; style=&#8221;dark&#8221; gutter_size=&#8221;3&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]1.[\/vc_custom_heading][vc_column_text]M\u00e9lanome du membre avec m\u00e9tastases en transit (phase IIIA, selon le syst\u00e8me de classification du MD Anderson Cancer Center)[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; back_color=&#8221;color-gyho&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]2.[\/vc_custom_heading][vc_column_text]M\u00e9lanome du membre avec m\u00e9tastases en transit aux ganglions r\u00e9gionaux (phase IIIB, selon le MD Anderson Cancer Center).[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; style=&#8221;dark&#8221; gutter_size=&#8221;3&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]3.[\/vc_custom_heading][vc_column_text]Association des deux phases cit\u00e9es ci-dessus (phase IIIAB, selon le syst\u00e8me de classification du MD Anderson Cancer Center).[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; back_color=&#8221;color-gyho&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]4.[\/vc_custom_heading][vc_column_text]Sarcomes primaires localement avanc\u00e9s et non r\u00e9s\u00e9cables du tissu mou du membre.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243; text_color=&#8221;color-163594&#8243;]Avantages de la perfusion des membres isol\u00e9s[\/vc_custom_heading][vc_column_text]Les avantages de perfusion des membres isol\u00e9s par rapport \u00e0 la chimioth\u00e9rapie syst\u00e9mique (par exemple n\u00e9o-adjuvante ou adjuvante) :[\/vc_column_text][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; equal_height=&#8221;yes&#8221; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; style=&#8221;dark&#8221; gutter_size=&#8221;3&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]1.[\/vc_custom_heading][vc_column_text]La possibilit\u00e9 d\u2019utiliser des concentrations beaucoup plus \u00e9lev\u00e9es, et donc beaucoup plus efficaces, de m\u00e9dicaments de chimioth\u00e9rapie cytotoxiques.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; back_color=&#8221;color-gyho&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]2.[\/vc_custom_heading][vc_column_text]L&#8217;absorption syst\u00e9mique r\u00e9duite du m\u00e9dicament cytotoxique (\u00e0 travers l\u2019isolement vasculaire et la perfusion s\u00e9lective du membre), entra\u00eenant une r\u00e9duction de la toxicit\u00e9 syst\u00e9mique.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; style=&#8221;dark&#8221; gutter_size=&#8221;3&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]3.[\/vc_custom_heading][vc_column_text]La possibilit\u00e9 d\u2019\u00e9liminer, \u00e0 la fin de la proc\u00e9dure, le m\u00e9dicament qui n\u2019a pas \u00e9t\u00e9 absorb\u00e9 par le membre.[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; back_color=&#8221;color-gyho&#8221; overlay_alpha=&#8221;50&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/4&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;400&#8243;]4.[\/vc_custom_heading][vc_column_text]La possibilit\u00e9 d\u2019administrer au niveau r\u00e9gional le m\u00e9dicament \u00e0 une temp\u00e9rature \u00e9lev\u00e9e, en augmentant aussi bien son activit\u00e9 cytotoxique que sa p\u00e9n\u00e9tration dans la masse tumorale.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243; text_color=&#8221;color-163594&#8243;]M\u00e9dicaments cytotoxiques utilis\u00e9s dans la perfusion des membres isol\u00e9s[\/vc_custom_heading][vc_column_text]Les m\u00e9dicaments commun\u00e9ment utilis\u00e9s dans l\u2019ILP sont le <strong>Melphalan et\/ou Doxorubicin<\/strong>. A cause de sa toxicit\u00e9 syst\u00e9mique, l\u2019injection suppl\u00e9mentaire du Tumor Necrosis Factor-\u03b1 (TNF-\u03b1) dans l\u2019ILP doit \u00eatre effectu\u00e9e uniquement apr\u00e8s l\u2019isolement vasculaire complet et le contr\u00f4le des pertes de sang. La perte de sang du membre isol\u00e9 est contr\u00f4l\u00e9e apr\u00e8s l\u2019injection d\u2019albumine radiomarqu\u00e9e et seule la d\u00e9tection de moins de 10% de la radioactivit\u00e9 dans la circulation syst\u00e9mique est consid\u00e9r\u00e9e s\u00fbre pour le patient.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_separator][\/vc_column][\/vc_row][vc_row unlock_row_content=&#8221;yes&#8221; row_height_percent=&#8221;40&#8243; parallax=&#8221;yes&#8221; overlay_alpha=&#8221;45&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243;][vc_column column_width_percent=&#8221;100&#8243; position_vertical=&#8221;middle&#8221; align_horizontal=&#8221;align_center&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; medium_width=&#8221;0&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;div&#8221; text_weight=&#8221;300&#8243; text_transform=&#8221;uppercase&#8221;]VOUS DESIREZ AVOIR PLUS D\u2019INFORMATIONS ?[\/vc_custom_heading][vc_button button_color=&#8221;color-692600&#8243; size=&#8221;btn-lg&#8221; border_animation=&#8221;btn-ripple-out&#8221; link=&#8221;url:mailto%3Ainfo%40rand-biotech.com|||&#8221;]ENVOYEZ UN E-MAIL[\/vc_button][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/1&#8243;][vc_custom_heading heading_semantic=&#8221;h1&#8243; text_size=&#8221;h1&#8243; text_weight=&#8221;300&#8243;]PERFUSION DE MEMBRE ISOLE[\/vc_custom_heading][vc_separator sep_color=&#8221;color-wvjs&#8221; el_width=&#8221;200px&#8221; el_height=&#8221;2&#8243;][vc_column_text]La perfusion d\u2019un membre isol\u00e9 est obtenue gr\u00e2ce \u00e0 la [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":1964,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1986","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La perfusion d\u2019un membre isol\u00e9 est obtenue gr\u00e2ce \u00e0 la canulation chirurgicale des deux principaux vaisseaux<\/title>\n<meta name=\"description\" content=\"L\u2019ILP est la proc\u00e9dure la plus efficace pour obtenir un contr\u00f4le local et afin de pouvoir sauver les membres\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rand-biotech.com\/fr\/rand-biotech-innovation-dans-la-technologie-medicale\/ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La perfusion d\u2019un membre isol\u00e9 est obtenue gr\u00e2ce \u00e0 la canulation chirurgicale des deux principaux vaisseaux\" \/>\n<meta property=\"og:description\" content=\"L\u2019ILP est la proc\u00e9dure la plus efficace pour obtenir un contr\u00f4le local et afin de pouvoir sauver les membres\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rand-biotech.com\/fr\/rand-biotech-innovation-dans-la-technologie-medicale\/ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb\/\" \/>\n<meta property=\"og:site_name\" content=\"RAND\" \/>\n<meta property=\"article:modified_time\" content=\"2017-09-28T10:17:54+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/rand-biotech.com\\\/fr\\\/rand-biotech-innovation-dans-la-technologie-medicale\\\/ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb\\\/\",\"url\":\"https:\\\/\\\/rand-biotech.com\\\/fr\\\/rand-biotech-innovation-dans-la-technologie-medicale\\\/ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb\\\/\",\"name\":\"La perfusion d\u2019un membre isol\u00e9 est obtenue gr\u00e2ce \u00e0 la canulation chirurgicale des deux principaux vaisseaux\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/rand-biotech.com\\\/#website\"},\"datePublished\":\"2016-10-15T22:41:45+00:00\",\"dateModified\":\"2017-09-28T10:17:54+00:00\",\"description\":\"L\u2019ILP est la proc\u00e9dure la plus efficace pour obtenir un contr\u00f4le local et afin de pouvoir sauver les membres\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/rand-biotech.com\\\/fr\\\/rand-biotech-innovation-dans-la-technologie-medicale\\\/ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/rand-biotech.com\\\/fr\\\/rand-biotech-innovation-dans-la-technologie-medicale\\\/ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/rand-biotech.com\\\/fr\\\/rand-biotech-innovation-dans-la-technologie-medicale\\\/ilp-perfusion-de-membre-isole-melanoma-and-soft-tissue-sarcomas-of-the-limb\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/rand-biotech.com\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"HOME &#8211; 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